Brand Name | Status | Last Update |
---|---|---|
carbaglu | New Drug Application | 2024-01-25 |
carglumic acid | ANDA | 2024-03-23 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
hyperammonemia | HP_0001987 | D022124 | E72.20 |
Expiration | Code | ||
---|---|---|---|
CARGLUMIC ACID, CARBAGLU, RECORDATI RARE | |||
2028-01-22 | ODE-345 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Acidosis | D000138 | EFO_1000014 | E87.2 | — | 3 | 1 | — | 3 | 7 |
Propionic acidemia | D056693 | — | E71.121 | — | 3 | 1 | — | 3 | 7 |
Inborn errors amino acid metabolism | D000592 | — | E72.9 | — | 1 | 1 | — | 2 | 4 |
Hyperammonemia | D022124 | HP_0001987 | E72.20 | — | 2 | 1 | — | 1 | 3 |
Inborn errors metabolism | D008661 | — | — | — | 2 | 1 | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Carbamoyl-phosphate synthase i deficiency disease | D020165 | EFO_0007193 | — | — | 2 | — | — | — | 2 |
Ornithine carbamoyltransferase deficiency disease | D020163 | EFO_0007409 | E72.4 | — | 1 | — | — | — | 1 |
Deficiency diseases | D003677 | EFO_1001067 | E63 | — | 1 | — | — | — | 1 |
Inborn urea cycle disorders | D056806 | — | E72.2 | — | 1 | — | — | — | 1 |
Drug common name | Carglumic acid |
INN | carglumic acid |
Description | Carglumic acid is a urea that is the N-carbamoyl derivative of L-glutamic acid. An orphan drug used to treat a deficiency in the enzyme N-acetylglutamate synthase, which leads to acute hyperammonaemia. It has a role as an orphan drug and a carbamylphosphate synthetase I activator. It is a N-acyl-L-glutamic acid and a member of ureas. |
Classification | Small molecule |
Drug class | — |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | NC(=O)N[C@@H](CCC(=O)O)C(=O)O |
PDB | — |
CAS-ID | 1188-38-1 |
RxCUI | — |
ChEMBL ID | CHEMBL1201780 |
ChEBI ID | 71028 |
PubChem CID | 121396 |
DrugBank | DB06775 |
UNII ID | 5L0HB4V1EW (ChemIDplus, GSRS) |